Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs

ITP OpenIR > SCI期刊论文

	Xue, Xiao Chuan; Tong, Huan; Liu, Fei; Ou-Yang, Zhong-can; Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
	Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs
Source Publication	JOURNAL OF PHYSICAL CHEMISTRY B
Keyword	Optical Tweezers Kinetics Models Dna
Abstract	On the basis of a coarse-grain physical model of the folding and unfolding of single-forced RNAs conducted in light tweezer experiments, we theoretically investigate the feasibility of inferring the RNA's intrinsic kinetic parameters from the noisy time series of the molecule's extension. A Bayesian approach using Monte Carlo Markov Chain is proposed. We prove that this statistical approach is efficient and accurate in inferring the molecule's physical parameters, even if the experimental data are yielded under a narrow range of forces.
	2008
ISSN	1520-6106
Volume	112 Issue:44 Pages:13680-13683
Subject Area	Physics
Indexed By	SCI
Funding Organization	Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045] ; Tsinghua Basic Research Foundation; National Science Foundation of China[10704045]
Citation statistics	Cited Times:1[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.itp.ac.cn/handle/311006/5440
Collection	SCI期刊论文
Corresponding Author	Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation GB/T 7714	Xue, Xiao Chuan,Tong, Huan,Liu, Fei,et al. Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(44):13680-13683.
APA	Xue, Xiao Chuan,Tong, Huan,Liu, Fei,Ou-Yang, Zhong-can,&Liu, F , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2008).Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs.JOURNAL OF PHYSICAL CHEMISTRY B,112(44),13680-13683.
MLA	Xue, Xiao Chuan,et al."Bayesian Analysis of Folding and Unfolding Time Series of Single-Forced RNAs".JOURNAL OF PHYSICAL CHEMISTRY B 112.44(2008):13680-13683.

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