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题名: A kinetic model of transcription initiation by RNA polymerase
作者: Xue, Xiao-chuan ;  Liu, Fei ;  Ou-Yang, Zhong-can
刊名: JOURNAL OF MOLECULAR BIOLOGY
出版日期: 2008
卷号: 378, 期号:3, 页码:520-529
关键词: SINGLE-MOLECULE ANALYSIS ;  ESCHERICHIA-COLI ;  ABORTIVE INITIATION ;  PROMOTER CLEARANCE ;  IN-VITRO ;  ELONGATION COMPLEX ;  BUBBLE COLLAPSE ;  DNA ;  ESCAPE ;  MECHANISM
学科分类: Physics
通讯作者: Xue, XC , Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
部门归属: [Xue, XC; Liu, F; Ou-Yang, ZC] Tsinghua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; [Ou-Yang, ZC] Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: We establish a sequence-dependent kinetic model for the later stage of transcription initiation by RNA polymerase. We suggest that there are three reaction pathways, the abortive pathway, the scrunching pathway and the escape pathway, competitive with each other at, each site during the transcription initiation. Using this three-pathway model, we mainly calculate the maximum sizes of the abortive transcripts, the abortive probabilities and the abortive/productive ratios for different promoters by Monte Carlo simulation and analytical methods. These results are quantitatively comparable with the experimental observations. In particular, our model can account for the unproductive initial transcribing complex and the nucleoside triphosphate concentration dependence of the transcription initiation, which have been found in the experiments and were hardly understood by the previous two-pathway kinetic competition model. (C) 2008 Elsevier Ltd. All rights reserved.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000255965600004
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/5535
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Xue, Xiao-chuan,Liu, Fei,Ou-Yang, Zhong-can. A kinetic model of transcription initiation by RNA polymerase[J]. JOURNAL OF MOLECULAR BIOLOGY,2008,378(3):520-529.
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