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Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments
Liu, Fei; Ou-Yang, Zhong-Can; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
2006
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号74期号:5页码:-
摘要Recent experiments found that some adhesive receptor-ligand complexes have counterintuitive catch-slip transition behaviors: the mean lifetimes of these complexes first increase (catch) with initial application of a small external force, and then decrease (slip) when the force is beyond some threshold. In this work we suggest that the forced dissociation of these complexes might be a typical rate process with dynamic disorder. The one-dimensional force modulating Agmon-Hopfield model is used to describe the transitions in the single-bond P-selectin glycoprotein ligand 1-P-selectin forced dissociation experiments, which were respectively performed in the constant force [Marshall , Nature (Landon) 423, 190 (2003)] and the ramping force [Evans , Proc. Natl. Acad. Sci. U.S.A 98, 11281 (2004)] modes. We find that, an external force can not only accelerate the bond dissociation, but also modulate the complex from the lower-energy barrier to the higher one; the catch-slip bond transition can arise from a particular energy barrier shape. The agreement between our calculation and the experimental data is satisfactory.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Cell-adhesion Molecules L-selectin Shear Lifetime Kinetics Flow
学科领域Physics
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收录类别SCI
WOS记录号WOS:000242408700074
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/5867
专题理论物理所SCI论文
通讯作者Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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Liu, Fei,Ou-Yang, Zhong-Can,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China. Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,74(5):-.
APA Liu, Fei,Ou-Yang, Zhong-Can,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,74(5),-.
MLA Liu, Fei,et al."Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 74.5(2006):-.
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