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题名: Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments
作者: Liu, Fei ;  Ou-Yang, Zhong-Can
刊名: PHYSICAL REVIEW E
出版日期: 2006
卷号: 74, 期号:5, 页码:-
关键词: CELL-ADHESION MOLECULES ;  L-SELECTIN ;  SHEAR ;  LIFETIME ;  KINETICS ;  FLOW
学科分类: Physics
通讯作者: Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
部门归属: Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: Recent experiments found that some adhesive receptor-ligand complexes have counterintuitive catch-slip transition behaviors: the mean lifetimes of these complexes first increase (catch) with initial application of a small external force, and then decrease (slip) when the force is beyond some threshold. In this work we suggest that the forced dissociation of these complexes might be a typical rate process with dynamic disorder. The one-dimensional force modulating Agmon-Hopfield model is used to describe the transitions in the single-bond P-selectin glycoprotein ligand 1-P-selectin forced dissociation experiments, which were respectively performed in the constant force [Marshall , Nature (Landon) 423, 190 (2003)] and the ramping force [Evans , Proc. Natl. Acad. Sci. U.S.A 98, 11281 (2004)] modes. We find that, an external force can not only accelerate the bond dissociation, but also modulate the complex from the lower-energy barrier to the higher one; the catch-slip bond transition can arise from a particular energy barrier shape. The agreement between our calculation and the experimental data is satisfactory.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000242408700074
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/5867
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Liu, Fei,Ou-Yang, Zhong-Can. Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,74(5):-.
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