Knowledge Management System of Institute of Theoretical Physics, CAS
Liu, Fei; Ou-Yang, Zhong-Can ; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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| Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments | |
| Source Publication | PHYSICAL REVIEW E
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| Keyword | Cell-adhesion Molecules L-selectin Shear Lifetime Kinetics Flow |
| Abstract | Recent experiments found that some adhesive receptor-ligand complexes have counterintuitive catch-slip transition behaviors: the mean lifetimes of these complexes first increase (catch) with initial application of a small external force, and then decrease (slip) when the force is beyond some threshold. In this work we suggest that the forced dissociation of these complexes might be a typical rate process with dynamic disorder. The one-dimensional force modulating Agmon-Hopfield model is used to describe the transitions in the single-bond P-selectin glycoprotein ligand 1-P-selectin forced dissociation experiments, which were respectively performed in the constant force [Marshall , Nature (Landon) 423, 190 (2003)] and the ramping force [Evans , Proc. Natl. Acad. Sci. U.S.A 98, 11281 (2004)] modes. We find that, an external force can not only accelerate the bond dissociation, but also modulate the complex from the lower-energy barrier to the higher one; the catch-slip bond transition can arise from a particular energy barrier shape. The agreement between our calculation and the experimental data is satisfactory. |
| 2006 | |
| ISSN | 1539-3755 |
| Volume | 74Issue:5Pages:- |
| Subject Area | Physics |
| Indexed By | SCI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.itp.ac.cn/handle/311006/5867 |
| Collection | SCI期刊论文 |
| Corresponding Author | Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Fei,Ou-Yang, Zhong-Can,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China. Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,74(5):-. |
| APA | Liu, Fei,Ou-Yang, Zhong-Can,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,74(5),-. |
| MLA | Liu, Fei,et al."Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 74.5(2006):-. |
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