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Single molecule Michaelis-Menten equation beyond quasistatic disorder
Xue, Xiaochuan; Liu, Fei; Ou-Yang, Zhong-can; Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
2006
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号74期号:3页码:-
摘要The classic Michaelis-Menten equation describes the catalytic activities for ensembles of enzyme molecules very well. But recent single-molecule experiments showed that the waiting time distribution and other properties of single enzyme molecules were not consistent with the prediction based on the ensemble viewpoint. They have contributed to the slow conformational changes of a single enzyme in the catalytic processes. In this work, we study the general dynamics of single enzymes in the presence of dynamic disorder. We find that, within the time separation regimes, i.e., the slow reaction and nondiffusion limits, the Michaelis-Menten equation holds exactly. In particular, by employing the decoupling approximation we demonstrate analytically that the classic Michaelis-Menten equation is still an excellent approximation in the presence of general dynamic disorder.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Electron-transfer Reactions Dynamics Kinetics Enzyme
学科领域Physics
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收录类别SCI
WOS记录号WOS:000240870100009
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/5916
专题理论物理所SCI论文
通讯作者Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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GB/T 7714
Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,et al. Single molecule Michaelis-Menten equation beyond quasistatic disorder[J]. PHYSICAL REVIEW E,2006,74(3):-.
APA Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,&Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Single molecule Michaelis-Menten equation beyond quasistatic disorder.PHYSICAL REVIEW E,74(3),-.
MLA Xue, Xiaochuan,et al."Single molecule Michaelis-Menten equation beyond quasistatic disorder".PHYSICAL REVIEW E 74.3(2006):-.
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