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Xue, Xiaochuan; Liu, Fei; Ou-Yang, Zhong-can; Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Single molecule Michaelis-Menten equation beyond quasistatic disorder
Source PublicationPHYSICAL REVIEW E
KeywordElectron-transfer Reactions Dynamics Kinetics Enzyme
AbstractThe classic Michaelis-Menten equation describes the catalytic activities for ensembles of enzyme molecules very well. But recent single-molecule experiments showed that the waiting time distribution and other properties of single enzyme molecules were not consistent with the prediction based on the ensemble viewpoint. They have contributed to the slow conformational changes of a single enzyme in the catalytic processes. In this work, we study the general dynamics of single enzymes in the presence of dynamic disorder. We find that, within the time separation regimes, i.e., the slow reaction and nondiffusion limits, the Michaelis-Menten equation holds exactly. In particular, by employing the decoupling approximation we demonstrate analytically that the classic Michaelis-Menten equation is still an excellent approximation in the presence of general dynamic disorder.
2006
ISSN1539-3755
Volume74Issue:3Pages:-
Subject AreaPhysics
Indexed BySCI
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/5916
CollectionSCI期刊论文
Corresponding AuthorXue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,et al. Single molecule Michaelis-Menten equation beyond quasistatic disorder[J]. PHYSICAL REVIEW E,2006,74(3):-.
APA Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,&Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Single molecule Michaelis-Menten equation beyond quasistatic disorder.PHYSICAL REVIEW E,74(3),-.
MLA Xue, Xiaochuan,et al."Single molecule Michaelis-Menten equation beyond quasistatic disorder".PHYSICAL REVIEW E 74.3(2006):-.
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