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Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S
Yong, Y; Dai, LR; Iwamoto, M; Ou-Yang, ZC; Ou-Yang, ZC , Chinese Acad Sci, Interdisciplinary Ctr Theoret Studies, POB 2735, Beijing 100864, Peoples R China
2006
发表期刊THIN SOLID FILMS
ISSN0040-6090
卷号499期号:40910页码:224-228
摘要The single point mutation F198S in prion protein can induce aberrant 3-dimensional structure which finally lead to serious disease. One of the most significant differences between normal and abnormal structures is the concentration of alpha-helix and beta-sheet. By employing molecular dynamics method, we studied the structural transition induced by the mutation F198S. Our results show that the loss of the hydrophobic interactions between the 198-th residue and its surroundings may lead to the transition. A creation of additional beta-sheet is captured in our investigation which has not been reported in the dynamical studies of mutated induced structure conversion in prion protein. (c) 2005 Elsevier B.V All rights reserved.
部门归属Chinese Acad Sci, Interdisciplinary Ctr Theoret Studies, Beijing 100864, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; Tokyo Inst Technol, Dept Phys Elect, Meguro Ku, Tokyo 1528552, Japan; Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
关键词Protein Thermodynamics Simulation Conversion Features Model
学科领域Physics
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收录类别SCI
WOS记录号WOS:000235826500041
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/6019
专题理论物理所SCI论文
通讯作者Ou-Yang, ZC , Chinese Acad Sci, Interdisciplinary Ctr Theoret Studies, POB 2735, Beijing 100864, Peoples R China
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Yong, Y,Dai, LR,Iwamoto, M,et al. Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S[J]. THIN SOLID FILMS,2006,499(40910):224-228.
APA Yong, Y,Dai, LR,Iwamoto, M,Ou-Yang, ZC,&Ou-Yang, ZC , Chinese Acad Sci, Interdisciplinary Ctr Theoret Studies, POB 2735, Beijing 100864, Peoples R China.(2006).Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S.THIN SOLID FILMS,499(40910),224-228.
MLA Yong, Y,et al."Molecular dynamics study on the conformational transition of prion induced by the point mutation: F198S".THIN SOLID FILMS 499.40910(2006):224-228.
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