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Force unfolding single RNAs
Liu, F; Tong, H; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
2006
发表期刊BIOPHYSICAL JOURNAL
ISSN0006-3495
卷号90期号:6页码:1895-1902
摘要We develop a continue time Monte Carlo algorithm to simulate single RNAs unfolded by a time-dependent external force on the secondary structure level. Two recent unfolding RNA experiments carried out by Bustamante group are mainly investigated. We find that, in contrast to popular two-state assumption about the RNAs free energy landscape along the molecular extension, the molecules used in the experiments do not present apparent energy barriers. The strong cooperative folding and unfolding transitions of the RNAs observed in the experiments and in our simulations arise from the interaction of the molecules and the light trap. In addition, we also investigate the properties of Jarzynski's remarkable equality, whose experimental test has received considerable attention.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Free-energy Differences Secondary Structure Mechanical Force Nonequilibrium Measurements Chemical-reactions Molecules Simulations Constants Equality Barriers
学科领域Physics
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收录类别SCI
WOS记录号WOS:000235709500005
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/6025
专题理论物理所SCI论文
通讯作者Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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Liu, F,Tong, H,Ou-Yang, ZC,et al. Force unfolding single RNAs[J]. BIOPHYSICAL JOURNAL,2006,90(6):1895-1902.
APA Liu, F,Tong, H,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force unfolding single RNAs.BIOPHYSICAL JOURNAL,90(6),1895-1902.
MLA Liu, F,et al."Force unfolding single RNAs".BIOPHYSICAL JOURNAL 90.6(2006):1895-1902.
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