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题名: Force unfolding single RNAs
作者: Liu, F ;  Tong, H ;  Ou-Yang, ZC
刊名: BIOPHYSICAL JOURNAL
出版日期: 2006
卷号: 90, 期号:6, 页码:1895-1902
关键词: FREE-ENERGY DIFFERENCES ;  SECONDARY STRUCTURE ;  MECHANICAL FORCE ;  NONEQUILIBRIUM MEASUREMENTS ;  CHEMICAL-REACTIONS ;  MOLECULES ;  SIMULATIONS ;  CONSTANTS ;  EQUALITY ;  BARRIERS
学科分类: Physics
通讯作者: Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
部门归属: Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: We develop a continue time Monte Carlo algorithm to simulate single RNAs unfolded by a time-dependent external force on the secondary structure level. Two recent unfolding RNA experiments carried out by Bustamante group are mainly investigated. We find that, in contrast to popular two-state assumption about the RNAs free energy landscape along the molecular extension, the molecules used in the experiments do not present apparent energy barriers. The strong cooperative folding and unfolding transitions of the RNAs observed in the experiments and in our simulations arise from the interaction of the molecules and the light trap. In addition, we also investigate the properties of Jarzynski's remarkable equality, whose experimental test has received considerable attention.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000235709500005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/6025
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Liu, F,Tong, H,Ou-Yang, ZC. Force unfolding single RNAs[J]. BIOPHYSICAL JOURNAL,2006,90(6):1895-1902.
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