Force unfolding single RNAs

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	Liu, F; Tong, H; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
	Force unfolding single RNAs
Source Publication	BIOPHYSICAL JOURNAL
Keyword	Free-energy Differences Secondary Structure Mechanical Force Nonequilibrium Measurements Chemical-reactions Molecules Simulations Constants Equality Barriers
Abstract	We develop a continue time Monte Carlo algorithm to simulate single RNAs unfolded by a time-dependent external force on the secondary structure level. Two recent unfolding RNA experiments carried out by Bustamante group are mainly investigated. We find that, in contrast to popular two-state assumption about the RNAs free energy landscape along the molecular extension, the molecules used in the experiments do not present apparent energy barriers. The strong cooperative folding and unfolding transitions of the RNAs observed in the experiments and in our simulations arise from the interaction of the molecules and the light trap. In addition, we also investigate the properties of Jarzynski's remarkable equality, whose experimental test has received considerable attention.
	2006
ISSN	0006-3495
Volume	90 Issue:6 Pages:1895-1902
Subject Area	Physics
Indexed By	SCI
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.itp.ac.cn/handle/311006/6025
Collection	SCI期刊论文
Corresponding Author	Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation GB/T 7714	Liu, F,Tong, H,Ou-Yang, ZC,et al. Force unfolding single RNAs[J]. BIOPHYSICAL JOURNAL,2006,90(6):1895-1902.
APA	Liu, F,Tong, H,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force unfolding single RNAs.BIOPHYSICAL JOURNAL,90(6),1895-1902.
MLA	Liu, F,et al."Force unfolding single RNAs".BIOPHYSICAL JOURNAL 90.6(2006):1895-1902.

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