ITP OpenIR  > SCI期刊论文
Liu, F; Tong, H; Ou-Yang, ZC; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Force unfolding single RNAs
KeywordFree-energy Differences Secondary Structure Mechanical Force Nonequilibrium Measurements Chemical-reactions Molecules Simulations Constants Equality Barriers
AbstractWe develop a continue time Monte Carlo algorithm to simulate single RNAs unfolded by a time-dependent external force on the secondary structure level. Two recent unfolding RNA experiments carried out by Bustamante group are mainly investigated. We find that, in contrast to popular two-state assumption about the RNAs free energy landscape along the molecular extension, the molecules used in the experiments do not present apparent energy barriers. The strong cooperative folding and unfolding transitions of the RNAs observed in the experiments and in our simulations arise from the interaction of the molecules and the light trap. In addition, we also investigate the properties of Jarzynski's remarkable equality, whose experimental test has received considerable attention.
Subject AreaPhysics
Indexed BySCI
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Liu, F,Tong, H,Ou-Yang, ZC,et al. Force unfolding single RNAs[J]. BIOPHYSICAL JOURNAL,2006,90(6):1895-1902.
APA Liu, F,Tong, H,Ou-Yang, ZC,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force unfolding single RNAs.BIOPHYSICAL JOURNAL,90(6),1895-1902.
MLA Liu, F,et al."Force unfolding single RNAs".BIOPHYSICAL JOURNAL 90.6(2006):1895-1902.
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