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题名: Dynamic disorder in receptor-ligand forced dissociation experiments
作者: Liu, F ;  Ou-Yang, ZC ;  Iwamoto, M
刊名: PHYSICAL REVIEW E
出版日期: 2006
卷号: 73, 期号:1, 页码:-
关键词: CELL-ADHESION MOLECULES ;  BONDS ;  CATCH ;  TRANSITION ;  KINETICS ;  MODEL
学科分类: Physics
通讯作者: Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
部门归属: Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; Tokyo Inst Technol, Dept Phys Elect, Meguro Ku, Tokyo 1528552, Japan
英文摘要: Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch bond" to the "slip bond." In this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1-P-selectin force rupture experiment [Marshall , Nature 423, 190 (2003)]. Our model agrees well with the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or a priori catch bond assumption is not essential.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000235008500007
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/6064
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Liu, F,Ou-Yang, ZC,Iwamoto, M. Dynamic disorder in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,73(1):-.
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