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Dynamic disorder in receptor-ligand forced dissociation experiments
Liu, F; Ou-Yang, ZC; Iwamoto, M; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
2006
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号73期号:1页码:-
摘要Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch bond" to the "slip bond." In this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1-P-selectin force rupture experiment [Marshall , Nature 423, 190 (2003)]. Our model agrees well with the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or a priori catch bond assumption is not essential.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China; Tokyo Inst Technol, Dept Phys Elect, Meguro Ku, Tokyo 1528552, Japan
关键词Cell-adhesion Molecules Bonds Catch Transition Kinetics Model
学科领域Physics
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收录类别SCI
WOS记录号WOS:000235008500007
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/6064
专题理论物理所SCI论文
通讯作者Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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GB/T 7714
Liu, F,Ou-Yang, ZC,Iwamoto, M,et al. Dynamic disorder in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,73(1):-.
APA Liu, F,Ou-Yang, ZC,Iwamoto, M,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Dynamic disorder in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,73(1),-.
MLA Liu, F,et al."Dynamic disorder in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 73.1(2006):-.
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