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Liu, F; Ou-Yang, ZC; Iwamoto, M; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Dynamic disorder in receptor-ligand forced dissociation experiments
Source PublicationPHYSICAL REVIEW E
KeywordCell-adhesion Molecules Bonds Catch Transition Kinetics Model
AbstractRecently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch bond" to the "slip bond." In this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1-P-selectin force rupture experiment [Marshall , Nature 423, 190 (2003)]. Our model agrees well with the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or a priori catch bond assumption is not essential.
2006
ISSN1539-3755
Volume73Issue:1Pages:-
Subject AreaPhysics
Indexed BySCI
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/6064
CollectionSCI期刊论文
Corresponding AuthorLiu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Liu, F,Ou-Yang, ZC,Iwamoto, M,et al. Dynamic disorder in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,73(1):-.
APA Liu, F,Ou-Yang, ZC,Iwamoto, M,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Dynamic disorder in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,73(1),-.
MLA Liu, F,et al."Dynamic disorder in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 73.1(2006):-.
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