Classification of amino acids based on statistical results of known structures and cooperativity of protein folding

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	Chen, H; Zhou, X; Ou-Yang, ZC; Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
	Classification of amino acids based on statistical results of known structures and cooperativity of protein folding
发表期刊	PHYSICAL REVIEW E
关键词	Secondary-structure Globular-proteins Model Sequences Conformation Parameters Copolymers Range
摘要	It has been found that the 20 kinds of amino acids have different frequencies of occurrence in alpha,beta, and coil structures [P. Y. Chou and G. D. Fasman, Biochemistry 13, 211 (1974)]. Based on more known structures of proteins, frequencies for each amino acid in alpha and beta secondary structures are recalculated. Next step, under the approximation ignoring the chain connectivity of proteins, energy parameters to form alpha and beta secondary structures for each amino acid are obtained. According to the hydrophobicity and energies in alpha and beta secondary structures, 20 kinds of amino acids are classified. The results suggest that dividing amino acids to five or nine groups is desirable. At last, a protein model considering both two-body hydrophobic interaction and one-body energy to form secondary structures, hydrophobic-polar alphabeta model, is introduced. It is shown that the consistency among various energy terms makes the cooperativity of protein folding closer to the experiments.
	2002
ISSN	1539-3755
卷号	65 期号:6 页码:-
学科领域	Physics
收录类别	SCI
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.itp.ac.cn/handle/311006/13512
专题	SCI期刊论文
通讯作者	Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
推荐引用方式 GB/T 7714	Chen, H,Zhou, X,Ou-Yang, ZC,et al. Classification of amino acids based on statistical results of known structures and cooperativity of protein folding[J]. PHYSICAL REVIEW E,2002,65(6):-.
APA	Chen, H,Zhou, X,Ou-Yang, ZC,&Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2002).Classification of amino acids based on statistical results of known structures and cooperativity of protein folding.PHYSICAL REVIEW E,65(6),-.
MLA	Chen, H,et al."Classification of amino acids based on statistical results of known structures and cooperativity of protein folding".PHYSICAL REVIEW E 65.6(2002):-.

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