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Classification of amino acids based on statistical results of known structures and cooperativity of protein folding
Chen, H; Zhou, X; Ou-Yang, ZC; Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
2002
发表期刊PHYSICAL REVIEW E
ISSN1539-3755
卷号65期号:6页码:-
摘要It has been found that the 20 kinds of amino acids have different frequencies of occurrence in alpha,beta, and coil structures [P. Y. Chou and G. D. Fasman, Biochemistry 13, 211 (1974)]. Based on more known structures of proteins, frequencies for each amino acid in alpha and beta secondary structures are recalculated. Next step, under the approximation ignoring the chain connectivity of proteins, energy parameters to form alpha and beta secondary structures for each amino acid are obtained. According to the hydrophobicity and energies in alpha and beta secondary structures, 20 kinds of amino acids are classified. The results suggest that dividing amino acids to five or nine groups is desirable. At last, a protein model considering both two-body hydrophobic interaction and one-body energy to form secondary structures, hydrophobic-polar alphabeta model, is introduced. It is shown that the consistency among various energy terms makes the cooperativity of protein folding closer to the experiments.
部门归属Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China
关键词Secondary-structure Globular-proteins Model Sequences Conformation Parameters Copolymers Range
学科领域Physics
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收录类别SCI
WOS记录号WOS:000176762500070
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.itp.ac.cn/handle/311006/13512
专题理论物理所1978-2010年知识产出
通讯作者Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
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GB/T 7714
Chen, H,Zhou, X,Ou-Yang, ZC,et al. Classification of amino acids based on statistical results of known structures and cooperativity of protein folding[J]. PHYSICAL REVIEW E,2002,65(6):-.
APA Chen, H,Zhou, X,Ou-Yang, ZC,&Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2002).Classification of amino acids based on statistical results of known structures and cooperativity of protein folding.PHYSICAL REVIEW E,65(6),-.
MLA Chen, H,et al."Classification of amino acids based on statistical results of known structures and cooperativity of protein folding".PHYSICAL REVIEW E 65.6(2002):-.
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