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题名: Classification of amino acids based on statistical results of known structures and cooperativity of protein folding
作者: Chen, H ;  Zhou, X ;  Ou-Yang, ZC
刊名: PHYSICAL REVIEW E
出版日期: 2002
卷号: 65, 期号:6, 页码:-
关键词: SECONDARY-STRUCTURE ;  GLOBULAR-PROTEINS ;  MODEL ;  SEQUENCES ;  CONFORMATION ;  PARAMETERS ;  COPOLYMERS ;  RANGE
学科分类: Physics
通讯作者: Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
部门归属: Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China; Acad Sinica, Inst Theoret Phys, Beijing 100080, Peoples R China
英文摘要: It has been found that the 20 kinds of amino acids have different frequencies of occurrence in alpha,beta, and coil structures [P. Y. Chou and G. D. Fasman, Biochemistry 13, 211 (1974)]. Based on more known structures of proteins, frequencies for each amino acid in alpha and beta secondary structures are recalculated. Next step, under the approximation ignoring the chain connectivity of proteins, energy parameters to form alpha and beta secondary structures for each amino acid are obtained. According to the hydrophobicity and energies in alpha and beta secondary structures, 20 kinds of amino acids are classified. The results suggest that dividing amino acids to five or nine groups is desirable. At last, a protein model considering both two-body hydrophobic interaction and one-body energy to form secondary structures, hydrophobic-polar alphabeta model, is introduced. It is shown that the consistency among various energy terms makes the cooperativity of protein folding closer to the experiments.
收录类别: SCI
原文出处: 查看原文
WOS记录号: WOS:000176762500070
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.itp.ac.cn/handle/311006/13512
Appears in Collections:理论物理所1978-2010年知识产出_期刊论文

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Recommended Citation:
Chen, H,Zhou, X,Ou-Yang, ZC. Classification of amino acids based on statistical results of known structures and cooperativity of protein folding[J]. PHYSICAL REVIEW E,2002,65(6):-.
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