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Li, M; Ou-Yang, ZC; Shu, YG
Advances in the study of the mechanochemical coupling of kinesin
Source PublicationINTERNATIONAL JOURNAL OF MODERN PHYSICS B
Language英语
KeywordSQUID GIANT-AXON BOVINE BRAIN KINESIN HAND-OVER-HAND CRYSTAL-STRUCTURE MOTOR DOMAIN NECK LINKER 8-NM STEP MOLECULAR MOTORS OPTICAL-TRAP FORCE
AbstractKinesin is a two-headed linear motor for intracellular transport. It can walk a long distance in a hand-over-hand manner along the track before detaching (i.e., high processivity), and it consumes one ATP molecule for each step (i.e., tight mechanochemical coupling). The mechanisms of the coordination of its two heads and the mechanochemical coupling are the central issues of numerous researches. A few advances have been made in recent decades, thanks to the development of single-molecule technologies and molecular dynamics simulations. In this paper, we review some progress of the studies on the kinematics, energetics, coordination mechanism, mechanochemical mechanism of kinesin. We also present a personal perspective on the future studies of kinesin.
2018
ISSN0217-9792
Volume32Issue:18Pages:1840001
Subject AreaPhysics
MOST Discipline CataloguePhysics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
DOI10.1142/S0217979218400015
Indexed BySCIE
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Document Type期刊论文
Identifierhttp://ir.itp.ac.cn/handle/311006/22856
Collection理论物理所科研产出_SCI论文
Affiliation1.[Li, Ming
2.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China
3.[Ou-Yang, Zhong-Can
4.Chinese Acad Sci, Inst Theoret Phys, CAS Key Lab Theoret Phys, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, M,Ou-Yang, ZC,Shu, YG. Advances in the study of the mechanochemical coupling of kinesin[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2018,32(18):1840001.
APA Li, M,Ou-Yang, ZC,&Shu, YG.(2018).Advances in the study of the mechanochemical coupling of kinesin.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,32(18),1840001.
MLA Li, M,et al."Advances in the study of the mechanochemical coupling of kinesin".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 32.18(2018):1840001.
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